What is the meaning of Vicissitude?

Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange; variability.

A change, especially in one's life or fortunes.

vicissitude

vicissitude

variation (change that occurs in things that happen)

chance, eventuality

adversity, reversal (change of circumstances or conditions, usually unfavorable)

setback

Source: wiktionary.org