What is the meaning of Anathema?

A ban or curse pronounced with religious solemnity by ecclesiastical authority, often accompanied by excommunication; something denounced as accursed.

Something which is vehemently disliked by somebody.

An imprecation; a curse; a malediction.

Any person or thing anathematized, or cursed by ecclesiastical authority to unending punishment.

offering (especially the life of a person)

curse

excommunication

Source: wiktionary.org