What is the meaning of さま?

a person's appearance

the state or situation of a thing

the general trend, tenor, or feel of a thing

one's social station, status, or quality

the way or means of doing something, how one does something

the reason or circumstances for something

second-person pronoun: you, you all

third-person distal pronoun: he, she, they

polite personal suffix: honorable, Mr., Ms.

attaching to nouns or other nominals: a politeness marker that often has no direct translation, replacing copula です (​desu)

attaching to specific nouns or other nominals: that way, that direction

attaching to verbs: just as

attaching to verbs: the way of doing something, how one does something

Source: wiktionary.org