What is the meaning of Nope?

No.

A negative reply, no.

An intensely undesirable thing, such as a circumstance or an animal, eliciting immediate repulsion without possibility of further consideration.

A bullfinch.

A blow to the head.

To hit someone on the head.

singular present subjunctive of nopen

nope

a tuft of wool; a knot in a fabric; nap

nope

Source: wiktionary.org