What is the meaning of Annihilate?

To reduce to nothing, to destroy, to eradicate.

To react with antimatter, producing gamma radiation and (for higher-mass reactants, especially composite particles such as protons) lighter particles (such as pions, muons, and neutrinos).

To treat as worthless, to vilify.

To render null and void; to abrogate.

second-person plural present active imperative of annihilō

Source: wiktionary.org