What is the meaning of Nuke?

A nuclear weapon.

Something that destroys or negates, especially on a catastrophic scale.

A nuclear power station.

A vessel such as a ship or submarine running on nuclear power.

A person (such as a sailor in a navy or a scientist) who works with nuclear weapons or nuclear power.

A cautionary flag placed on a release to label it as "bad" for some reason or another (e.g., being a dupe of a previous release or containing malware).

A microwave oven.

To use a nuclear weapon on (a target).

To destroy or erase completely.

To carry out a denial-of-service attack against (an IRC user).

To maliciously destroy an online community or chat server (especially on Discord) by mass-deleting channels, roles, and messages, or by mass-banning members, often using an automated script or bot.

To expose to some form of radiation.

To cook in a microwave oven.

To overanalyze or despair unduly over something.

Alternative spelling of nuc (“nucleus colony of bees”).

Alternative form of nucha (“spinal cord; nape of the neck”).

Alternative form of nook (“a corner of a piece of land; an angled piece of land, especially one extending into other land”).

first-person singular, with third-person singular direct object, hypothetic consequential indicative of izan (“to have”, transitive auxiliary)

synonym of ydinase (“nuclear weapon”)

Source: wiktionary.org